IMPACT OF GLYPHOSATE-BASED HERBICIDE ON THE REPRODUCTIVE SYSTEM AND SEMEN QUALITY OF WISTAR RATS

Document Type : Original Article

Authors

1 ABIDJAN/COCODY ABIDJAN/COCODY ABIDJAN/COCODY

2 URF Sciences et Technologie/ laboratoire de Sciences Biologiques Animales/ Université Alassane Ouattara/ Bouaké/ Cote d’Ivoire

3 UFR Biosciences/ Laboratoire de Biologie et Santé/ Université Félix Houphouët Boigny /Abidjan / Cote d’Ivoire

Abstract

This study was conducted as part of the toxicity assessment of a glyphosate-based herbicide commonly used in Ivory Coast. The objective of this study was to highlight the effects of Kalach, a glyphosate-based herbicide, on the reproductive system of Wistar rats. For this purpose, 32 male rats were divided into four groups of eight rats each. The control group received distilled water. The other three groups received 0.1 ml, 0.2 ml, and 0.3 ml of Kalach, corresponding to 250, 500, and 1000 mg/kg/day, respectively. Glyphosate treatment was carried out for 60 days. At the end of treatment, the testes, epididymis, seminal vesicles, and prostate were removed and weighed. Testosterone, LH, and FSH levels in blood serum were measured. Sperm concentration, morphology, and motility were determined. Histological sections of the testes were also taken. The results revealed a significant reduction in the relative mass of the testes, epididymis, seminal vesicles, and prostate in the treated groups compared to the control group. Serum FSH and testosterone concentrations were also decreased in the treated rats. Another decrease in sperm concentration, motility, and normal shapes was also recorded. Histological damage to the seminiferous tubules, impaired spermatogenesis, and a reduction in the epithelial height of the seminiferous tubules were observed. It was concluded that doses of 250, 500, and 1000 mg/kg body weight of glyphosate, Kalach, had an impact on the reproductive system of rats. It has been recommended that glyphosate-based herbicides be used with great caution and strict safety measures. otherwise, use environmentally friendly control methods.

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