Abdel-Rahman, S., Ashour, G., Abd El-Azeem, N., Barakat, S., M, D., G., M. (2022). PROTECTIVE EFFECT OF N-ACEETYLCYSTEIN AGAINST OXIDATIVE STRESS IN RELATION TO SEMEN CHARACTERISTICS IN NEW ZEALAND WHITE RABBITS. Egyptian Journal of Animal Production, 59(3), 121-130. doi: 10.21608/ejap.2022.147551.1043
Samah Abdel-Rahman; Gamal Ashour; Noha Abd El-Azeem; Safaa Barakat; Dessouki M; Mehaisen G.. "PROTECTIVE EFFECT OF N-ACEETYLCYSTEIN AGAINST OXIDATIVE STRESS IN RELATION TO SEMEN CHARACTERISTICS IN NEW ZEALAND WHITE RABBITS". Egyptian Journal of Animal Production, 59, 3, 2022, 121-130. doi: 10.21608/ejap.2022.147551.1043
Abdel-Rahman, S., Ashour, G., Abd El-Azeem, N., Barakat, S., M, D., G., M. (2022). 'PROTECTIVE EFFECT OF N-ACEETYLCYSTEIN AGAINST OXIDATIVE STRESS IN RELATION TO SEMEN CHARACTERISTICS IN NEW ZEALAND WHITE RABBITS', Egyptian Journal of Animal Production, 59(3), pp. 121-130. doi: 10.21608/ejap.2022.147551.1043
Abdel-Rahman, S., Ashour, G., Abd El-Azeem, N., Barakat, S., M, D., G., M. PROTECTIVE EFFECT OF N-ACEETYLCYSTEIN AGAINST OXIDATIVE STRESS IN RELATION TO SEMEN CHARACTERISTICS IN NEW ZEALAND WHITE RABBITS. Egyptian Journal of Animal Production, 2022; 59(3): 121-130. doi: 10.21608/ejap.2022.147551.1043
PROTECTIVE EFFECT OF N-ACEETYLCYSTEIN AGAINST OXIDATIVE STRESS IN RELATION TO SEMEN CHARACTERISTICS IN NEW ZEALAND WHITE RABBITS
1Animal Production Research Institute, Agricultural Research Center
2Animal Production Department, Faculty of Agriculture, Cairo University
Abstract
SUMMARY
A total of 15 mature New Zealand White (NZW) rabbit bucks, aged 6-8 months, weighing about 3.5 Kg were divided into three equal groups, control group (G1) that injected subcutaneously with saline solution, while bucks in G2 and G3 were injected subcutaneously with 50 and 100 mg NAC / kg body weight, respectively for seven consecutive days. Blood samples were collected at days 8and day 47, and semen characteristics were evaluated at day 48. The results revealed that there was a positive effect of NAC on antioxidant status through its obvious impact on MDA level that continuously decreased, in G3, from 6.10 to 3.58 nmol/ml, from zero day-to-day 47.While, G1 recorded continuous increase. Additionally, NAC injection with the dose of 100 mg/kg BW succeeded in elevating catalase activity that elevated from 329.8 to 372.4 U/L) on the 8th day compared to its levels in zero day. Moreover, H2O2 was insignificantly declined and this decline continued until the day 47 in G3 (declined from 0.093, at zero day to 0.083 mmol/L, at day 47) with stable level in G2 (0.098 mmol/L, at 8th and 47 days). No side effects of the NAC injections were detected as confirmed by normal activity of liver enzymes (ALT and AST) in rabbits. The same trend was noticed for kidney functions. Additionally, an enhancement of semen characteristics due to NAC injections was observed, especially in G3.
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